Established centres have opportunities to build relationships with emerging centres in developing countries and/or different cultural settings. Emerging centres want to learn from established ones and connect with their ideas and exhibitions. Science centres also work with educational and commercial organizations toward common goals. We will explore these relationships from various perspectives. Speakers in this session have first-hand experience in international initiatives. Cross-cultural collaborations present opportunities and challenges and alsoand also reap rich rewards for participants. Cultural differences between colleagues present challenges, as does working with other industry sectors and commercial/corporate clients. The experiences shared here will be immensely useful to both established and emerging science centres.