The goal of this report is to offer to all the partners of Sparks a common understanding of the technological shifts that are influencing the fields of health and medicine and of how RRI can be identified, discussed, and modelled in the activities that will be developed for Sparks. The report provides an overview of current and future trends at the intersection of technology, health, and medicine. These trends are contextualized in the practice of Responsible Research and Innovation (RRI). Thus the report provides descriptions of the content that local organizers of Sparks will come across during the project, along with inspiration and examples on how to identify additional content items, develop storylines, and engage stakeholders for the development of local exhibition components and programs.